Longevity and Down's syndrome

Anesthetic consideration in downs syndrome--a review.

Downs syndrome constitutes to be the most common chromosomal disorder. Patients with Downs's syndrome are posted for several surgeries including dental procedures and even for facial reconstruction. They are associated with several congenital anomalies in different organ system. There is also increased incidence of atlanto axial instability and risk of spinal cord injury. These children are sus...

The Ups and Downs of BDNF in Rett Syndrome

Rett syndrome (RTT) is an X-linked postnatal neurodevelopmental disorder, which is primarily caused by mutations in the gene encoding methyl-CpG binding protein 2 (MeCP2). A number of MeCP2 target genes have been identified, including the neurotrophic factor BDNF; however, the functional relevance of these targets has not been established. In this issue of Neuron, Chang et al. provide the first...

Mdm2: the ups and downs.

Mdm2 was first described 12 years ago. Interest in this oncogene has risen since its identification as a protein that binds and efficiently inactivates the p53 tumor suppressor protein. This interest was further boosted by the discovery that the mdm2 gene is actually a target for direct transcriptional activation by p53, thus defining an autoregulatory feedback loop for the intracellular modula...

Calorie Restriction, Longevity and Cognitive Function

Downs and Two-party Convergence

We take as our starting point the insights of Downs (1957) into twoparty competition. A careful reading of Downs offers a much more sophisticated and nuanced portrait of the factors affecting party differentiation than the simplistic notion that, in plurality elections, we ought to expect party convergence to the views of the median voter. Later scholars have built on Downsian ideas to see what...